Kyler Murray delivered an impressive performance, throwing for 242 yards and four touchdowns.
The Arizona Cardinals took control of the game, leading throughout the second half to secure a 47-24 victory over the injury-plagued San Francisco 49ers.
Despite the win, the Cardinals finish the season with an 8-9 record and miss the playoffs for the third consecutive year.
The 49ers wrapped up their season with a disappointing 6-11 record, losing seven of their last eight games.
Key contributions included two touchdown passes to Greg Dortch and a pivotal touchdown throw from Murray to Marvin Harrison Jr. in the final quarter.
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