A new study published in JAMA Network Open analyzed adolescent brain scans to investigate the gateway drug theory.
This theory posits that using substances like cannabis leads to harder drug use later in life, though its validity has come under scrutiny.
The research, conducted on nearly 10,000 adolescents, found that those who began using substances showed anatomical differences in their brains prior to that use.
Structural differences included a thinner prefrontal cortex and larger overall brain sizes, challenging previous assumptions about drug use effects.
Experts suggest a holistic view of substance use risk factors is needed, including genetics and environmental influences. Read more in the full article here.