• Iran's Supreme Leader Khamenei warns of "irreparable consequences" for US intervention.
• Israeli Defense Minister threatens elimination of Khamenei following missile strikes.
• Escalating tensions have led to significant casualties on both sides.

Iran's Supreme Leader Ayatollah Ali Khamenei has issued a stark warning regarding any direct U.S. involvement in the conflict with Israel, stating that it would result in "irreparable consequences." In a televised address, Khamenei emphasized that Iran would not tolerate foreign interventions, asserting, "The Americans must understand that any military intervention will undoubtedly bring irreversible harm," referring to U.S. President Donald Trump's recent demands for Iran's "unconditional surrender" and veiled threats against him, according to aa, Channel News Asia, and NPR.

In response to Khamenei's warnings, Israeli Defense Minister Israel Katz has escalated rhetoric against the Iranian leader, asserting that Khamenei "can no longer be allowed to exist." Katz's statements follow missile attacks from Iran that have targeted civilian areas, including hospitals in Israel, injuring dozens. He cited Khamenei's open intentions to destroy Israel, stating, "Such a man can no longer be allowed to exist," according to aa and Channel News Asia.

Since the conflict escalated with Israel's airstrikes on multiple Iranian sites, including military facilities and a nuclear reactor, casualties have been mounting. Reports indicate that around 585 Iranians have been killed in retaliatory airstrikes, with significant damage also sustained on the Israeli side, where at least 24 deaths have been reported due to Iranian missile attacks, according to aa and Newsweek.

The U.S. has remained cautious about direct involvement; Trump has suggested that while the U.S. is aware of Khamenei's whereabouts, immediate action is not planned. However, remarks from Israeli leaders suggest a willingness to consider all options in dealing with the Iranian regime, highlighting the increasing volatility in the region, as noted by Channel News Asia and TRT Global.

In light of these developments, the international community continues to watch closely as both sides prepare for further military actions, with U.S. officials advising Israel against any plans to assassinate Khamenei, emphasizing the complexities and potential fallout of direct military engagement, according to Channel News Asia and NPR.