• Gene Hackman's cause of death was confirmed as heart disease in the autopsy report.
• He also suffered from advanced Alzheimer's disease and prolonged fasting.
• Hackman's wife, Betsy Arakawa, died from hantavirus pulmonary syndrome on February 11.
• Both tested negative for alcohol and intoxicating drugs.
• The couple's deaths are under investigation, with reports indicating Hackman may have been unaware of his wife's passing.

The final autopsy report for Gene Hackman confirms that he died primarily from heart disease, highlighting his poor cardiovascular health with a history of congestive heart failure and irregular heartbeat. Additionally, he had undergone an aortic valve replacement and was implanted with a pacemaker in April 2019, as detailed by reports from newsweek and channelnewsasia.

Further findings from the autopsy revealed that Hackman was in the advanced stages of Alzheimer's disease and that there were trace amounts of acetone in his system, suggesting he had not eaten for an extended period. He tested negative for Hantavirus, which was responsible for his wife Betsy Arakawa's death on February 11, according to npr and channelnewsasia.

While Hackman survived longer than Arakawa, he appeared to have lived alone at home for about a week, possibly unaware of her death. On February 18, his pacemaker recorded an abnormal heart rhythm, indicating deterioration in his condition, as noted in reports from newsweek and npr.

The circumstances surrounding their deaths are still under investigation, with detectives examining evidence and interviewing individuals connected to the couple, according to channelnewsasia and newsweek.