Key Takeaways:

• Prince Frederik of Luxembourg died at 22 due to POLG mitochondrial disease.
• He was diagnosed at 14 and spent his life advocating for awareness and research on the illness.
• His passing occurred on March 1, one day after Rare Disease Day, reflecting his commitment to the cause.

Prince Frederik of Luxembourg, aged just 22, has succumbed to POLG mitochondrial disease, a rare and relentless genetic disorder he battled throughout his life. According to a statement from his father, Prince Robert, Frederik passed away on March 1 in Paris, the day following internationally recognized Rare Disease Day. This timing underscores his dedication to raising awareness about rare diseases, particularly POLG condition, which he sought to illuminate through his foundation established in 2021.

Diagnosed at the age of 14, Frederik faced a lifelong struggle with the disorder that significantly impairs the body's ability to produce energy, resulting in multiple organ dysfunction, as detailed by the New York Times. His father recounted the profound moment when Frederik gathered family to bid farewell, expressing his need for reassurance from his father, reflected through the poignant question, “Papa, are you proud of me?” This reflection captures the essence of his life's journey and the legacy he leaves behind.

Frederik was fondly remembered for his 'indomitable lust for life,' a trait that shone through even in his final days. He continued to engage with the world around him despite his declining health, demonstrated by his interest in learning Italian and the fondness for the American series "The Office," which he had watched multiple times. The India Times reported that Frederik was active in creating awareness about POLG disease, using his own experience and DNA for research initiatives.

The POLG Foundation, which he founded, has not only been pivotal in unsolicited research into the disease but also aimed to foster compassionate understanding surrounding it. The genetic disorder, affecting an estimated one in 10,000 people, is characterized by progressive symptoms such as seizures, weakness, and organ failure. The foundation added that the disease “robs the body’s cells of energy” similarly to a battery that is unable to recharge.

Prince Frederik’s legacy will continue to inspire efforts towards greater awareness and understanding of mitochondrial diseases globally, ensuring that his spirit and advocacy live on in the fight against rare disorders.

For more on this story, refer to the CBS News.