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Rethinking the Amyloid Hypothesis: New Perspectives in Alzheimer's Research

share-iconPublished: Saturday, January 11 share-iconUpdated: Saturday, January 11 comment-icon10 months ago
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SALON
Rethinking the Amyloid Hypothesis: New Perspectives in Alzheimer's Research

Credited from: SALON

  • Alzheimer’s disease is expected to affect 153 million adults globally by 2050, prompting urgent research and therapeutic development.
  • The amyloid cascade hypothesis, linking amyloid beta protein to Alzheimer’s, has faced criticism and controversies surrounding drug approvals and safety.
  • The FDA's approval of drugs like aducanumab was controversial due to mixed trial data, with concerns over safety risks such as brain swelling.
  • Recent research suggests that while amyloid may play a role in the disease, it is likely not the sole factor driving its progression.
  • The future of Alzheimer’s treatments may involve a multi-faceted approach, incorporating insights from immune responses and other factors linked to neurodegeneration.

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Alzheimer's Amyloid hypothesis Cognitive decline Drug safety Neurodegeneration Therapeutic research
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